If you’re flying RJ’s a lot, I’d go with a smaller alternative to the Air Boss (which I love, but you’ll likely have gate agents wanting you to check it). Michael’s suggestion is a good one – the GoLite bag is handsome, well made, and less expensive than the MLC. Here’s a link to my review, in case you haven’t seen it: http://is.gd/dkIFu
Also, it should certainly be well suited to the type of travel you do. Let us know what you decide – or if you have other questions.

Kevin

http://is.gd/dkITF

Nicer material (appearance) than the MLC, imho, I have both.

Mainly business casual. My trips are usually 3-5 days. Some within North America, and some in Europe. I’ve been using an Eagle Creek Twist Pack 22 (45″ linear inches total) with wheels and it also converts to a backpack which I’ve never used. Additionally, I use an Eagle Creek packing cube, a packing tube and a pack it folder. I also carry a Patagonia Backpack for my laptop and electronics. The bag, and wheels are great on the Twist Pack, but I feel like it’s somewhat cumbersome and it ALWAYS has to be checked on a Regional Jet. I also feel I lose some packing space due to the wheel mechanism and handle assembly. I’d like to consolidate everything into one bag, and don’t know which bag to purchase. I’ve seen the new Patagonia MLC first hand. It’s a handsome bag, with great features however, the material construction seemed a little “weak” and I questioned the bag’s durability based on the handle stitching etc. When I pulled on both handles, I hear a slight ripping or tearing noise. Doesn’t necessarily mean the bag is ripping, but it was a concern of mine. So, there you have it. Your two cents?